Trelagliptin
货号：
18504-1mg 基本售价：
686.0 元 规格：
1 mg
产品信息
概述| 货号 | 18504-1mg |
| 描述 | Dipeptidyl peptidase 4 (DPP-4) is an intrinsic membrane glycoprotein that acts as an exopeptidase, cleaving oligopeptides after the second amino acid from the N-terminal end. One of its substrates is glucagon-like peptide 1, an incretin that stimulates insulin biosynthesis and secretion while inhibiting glucagon release in a glucose-dependent manner. Trelagliptin is a pyrimidinedione-based, long-acting inhibitor of DPP-4 (IC50 = 4 nM).1 It demonstrates >10,000-fold selectivity over other peptidases.1 Trelagliptin has been used to improve glucose tolerance and postprandial plasma insulin levels in Zucker fa/farats.1 In 2014 this compound underwent phase III clinical trials.1 |
| 别名 | SYR-472; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kushwaha, R.N.,Haq, W., and Katti, S.B. Discovery of 17 gliptins in 17-years of research for the treatment of type 2 diabetes: A synthetic overview. Chemistry and Biology Interface 4(3), 137-162 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 357.4 |
| 分子式 | C18H20FN5O2 |
| CAS号 | 865759-25-7 |
| 稳定性 | ≥ 2 years |
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