| 货号 | 18469-500ug |
| 描述 | CA-074 methyl ester is a cell-permeable inhibitor of cathepsin B and L in vivo and in whole cells.1,2 The methyl ester is hydrolyzed by intracellular esterases releasing the active inhibitor, CA-074. This compound has primarily been used to study the role of cathepsin B in neurodegeneration, cancer cell metastasis, necrosis, and rheumatoid arthritis.3,4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Montaser, M.,Lalmanach, G., and Mach, L. CA-074, but not its methyl ester CA-074ME, is a selective inhibitor of cathepsin B within living cells. Biological Chemistry 383, 1305-1308 (2002). 2.Steverding, D. The cathepsin B-selective inhibitors CA-074 and CA-074Me inactivate cathepsin L under reducing conditions. Open Enzyme Inhibition Journal 4, 11-16 (2011). 3.Hook, V.Y.,Kindy, M., and Hook, G. Inhibitors of cathepsin B improve memory and reduce β-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, β-secretase site of the amyloid precursor protein. The Journal of Biological Chemisty 283(12), 7745-7753 (2008). 4.Szpaderska, A.M., and Frankfater, A. An intracellular form of cathepsin B contributes to invasiveness in cancer. Cancer Research 61, 3493-3500 (2001). 5.Hentze, H.,Lin, X.Y.,Choi, M.S.K., et al. Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death and Differentiation 10, 956-968 (2003). 6.Tong, B.,Wan, B.,Wei, Z., et al. Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis. Clinical and Experimental Immunology 177, 586-597 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.5 |
| 分子式 | C19H31N3O6 |
| CAS号 | 147859-80-1 |
| 稳定性 | ≥ 2 years |
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