| 货号 | 18422-1mg |
| 描述 | Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia.1,2 However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts.1 Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position.1 It inhibits SUMOylation in vitro(IC50 = 3 µM) and in cells without affecting protein ubiquitination.3,4 Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate.3 Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice.5 |
| 别名 | Anacardic Acid 15:1;Ginkgolic Acid I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.He, X.g.,Bernart, M.W.,Nolan, G.S., et al. High-performance liquid chromatography-electrospray ionization-mass spectrometry study of ginkgolic acid in the leaves and fruits of the ginkgo tree (Ginkgo biloba). J.Chromatogr.Sci. 38, 169-173 (2000). 2.Gauthier, S., and Schlaefke, S. Efficacy and tolerability of Ginkgo biloba extract EGb 761r in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials. Clinical Interventions in Aging 9, 2065-2077 (2014). 3.Fukuda, I.,Ito, A.,Hirai, G., et al. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chemistry & Biology 16, 133-140 (2009). 4.Luo, H.B.,Xia, Y.Y.,Shu, X.J., et al. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America 111(46), 16586-16591 (2014). 5.Ma, J.,Duan, W.,Han, S., et al. Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis. Oncotarget 6(25), 20993-21003 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 346.5 |
| 分子式 | C22H34O3 |
| CAS号 | 22910-60-7 |
| 稳定性 | ≥ 2 years |
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