| 货号 | 18381-5mg |
| 描述 | TheArabidopsis shaggy-related kinases (ASKs) are plant kinases that are structurally similar to a Drosophila kinase, shaggy, which has key roles in development. ASKs are also similar to glycogen synthase kinase 3 isoforms, which are found in plants as well as animals. Bikinin is an inhibitor of several ASK isoforms when given at a concentration of 10 µM.1 After bikinin treatment, residual kinase activity was less than 10% for ASKα, γ, ε, ζ, η, ι, and 20% for ASKθ, while isoforms β and δ were not affected. Bikinin has little or no direct effect on a wide range of other kinases.1 By inhibiting ASKs, bikinin activates signaling induced by the brassinosteroid, brassinolide.1 Bikinin blocks the phosphorylation of SnRK2.3 by ASKη (also known as BIN2), upregulating signaling through abscisic acid (Item No. 10073).2 Bikinin has been used to study the role of ASK-modulated brassinosteroid signaling in wheat and in viral infection of plants.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.De Rybel, B.,Audenaert, D.,Vert, G., et al. Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chemistry & Biology 16(6), 594-604 (2009). 2.Cai, Z.,Liu, J.,Wang, H., et al. GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 111(26), (2014). 3.Bittner, T.,Nadler, S.,Schulze, E., et al. Two homolog wheat glycogen synthase kinase 3/SHAGGY-like kinases are involved in brassinosteroid signaling. BMC Plant Biol. 15:247, (2015). 4.Mills-Lujan, K.,Andrews, D.L.,Chou, C.W., et al. The roles of phosphorylation and SHAGGY-like protein kinases in geminivirus C4 protein induced hyperplasia. PLoS One 10(3), (2015). 5.Deng, X.G.,Zhu, T.,Peng, X.J., et al. Role of brassinosteroid signaling in modulating Tobacco mosaic virus resistance in Nicotiana benthamiana. Sci.Rep. 6:20579, (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 273.1 |
| 分子式 | C9H9BrN2O3 |
| CAS号 | 188011-69-0 |
| 稳定性 | ≥ 2 years |
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