| 货号 | 17958-50mg |
| 描述 | Dyphylline is a xanthine derivative that acts as an A1 and A2 adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects.1,2 It also moderately inhibits microsomal prostaglandin E synthase-1 with an IC50 value of 200 µM and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.3,4 |
| 别名 | 7-(2,3-Dihydroxypropyl)theophylline;Dilor;Diprophylline;Lufyllin;Neothyllin;NSC 14305;NSC 40844; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cushley, M.J., and Holgate, S.T. Bronchodilator actions of xanthine derivatives administered by inhalation in asthma. Thorax. 40, 176-179 (1985). 2.Schwabe, U.,Ukena, D., and Lohse, M.J. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn-Schmiedebergs Arch.Pharmacol. 330, 212-221 (1985). 3.Ding, R.,Shi, J.,Pabon, K., et al. Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance. Molecular Pharmaceutics 81(3), 328-337 (2012). 4.Kim, W.I.,Choi, K.A.,Do, H.S., et al. Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library. BMB Reports 41(11), 808-813 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 254.2 |
| 分子式 | C10H14N4O4 |
| CAS号 | 479-18-5 |
| 稳定性 | ≥ 2 years |
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