VP-14637
货号：
17805-1mg 基本售价：
686.0 元 规格：
1 mg
产品信息
概述| 货号 | 17805-1mg |
| 描述 | Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. RSV F protein, which mediates fusion of the viral envelope with the host cell membrane, has become a target of anti-RSV treatment. VP-14637 is a small molecule inhibitor of RSV that demonstrates antiviral activity with an EC50 value of 1.4 nM.1,2 It interferes directly with RSV fusion (EC50 = 5.4 nM), binding to the viral F protein, which allows simultaneous interaction with both of the heptad repeat domains of the F protein trimer.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Douglas, J.L.,Panis, M.L.,Ho, E., et al. Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. Journal of Virology 77(9), 5054-5064 (2003).
2.Douglas, J.L.,Panis, M.L.,Ho, E., et al. Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. Antimicrobial Agents and Chemotherapy 49(6), 2460-2466 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 510.5 |
| 分子式 | C25H22N10O3 |
| CAS号 | 235106-62-4 |
| 稳定性 | ≥ 2 years |
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