| 货号 | 17779-5mg |
| 描述 | Sivelestat is a potent and selective inhibitor of neutrophil elastase (IC50 = 44 nM).1 It is without effect on a panel of related proteases.1 Sivelestat is effective in vivo, blocking elastase-dependent acute lung injury induced by intratracheal administration of LPS.1,2 Elastase inhibitors, including sivelestat, have clinical utility in protecting against direct or indirect lung injury, with or without concomitant sepsis.3,4,5 |
| 别名 | LY544349;ONO-5046; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kawabata, K.,Suzuki, M.,Sugitani, M., et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochemical and Biophysical Research Communications 177(2), 814-820 (1991). 2.Yasui, S.,Nagai, A.,Aoshiba, K., et al. A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster. European Respiratory Journal 8, 1293-1299 (1995). 3.Aikawa, N., and Kawasaki, Y. Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome. Ther.Clin.Risk Manag. 10, 621-629 (2014). 4.Miyoshi, S.,Hamada, H.,Ito, R., et al. Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. Drug Des.Devel.Ther. 7, 305-316 (2013). 5.Crocetti, L.,Schepetkin, I.A.,Cilibrizzi, A., et al. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. Journal of Medicinal Chemistry 56(15), 6259-6272 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 528.5 |
| 分子式 | C20H21N2O7S • Na [4H2O] |
| CAS号 | 201677-61-4 |
| 稳定性 | ≥ 2 years |
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