Ferrostatin-1
货号：
17729-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 17729-5mg |
| 描述 | Ferrostatin-1 inhibits a specific type of non-apoptotic, iron-dependent, oxidative cell death termed ferroptosis (IC50 = 60 nM), which is induced by the oncogenic Ras-selective compound, erastin (Item No. 17754).1 Ferrostatin-1 prevents ferroptosis in cancer cells as well as glutamate-induced cell death in organotypic rat brain slices.1 Ferrostatin-1 also inhibits cell death in models of Huntington’s disease, periventricular leukomalacia, and kidney dysfunction where it has been found to prevent the accumulation of cytosolic and lipid reactive oxygen species.2 |
| 别名 | Fer-1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dixon, S.J.,Lemberg, K.M.,Lamprecht, M.R., et al. Ferroptosis: An iron-dependent form of non-apoptotic cell death. Cell 149(5), 1060-1072 (2012).
2.Skouta, R.,Dixon, S.J.,Wang, J., et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. Journal of the American Chemical Society 136, 4551-4556 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 262.4 |
| 分子式 | C15H22N2O2 |
| CAS号 | 347174-05-4 |
| 稳定性 | ≥ 2 years |
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