PF-3716556
货号：
17710-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 17710-5mg |
| 描述 | PF-3716556 is a potent and selective hydrogen-potassium pump (H+/K+-ATPase) inhibitor in a new class of acid suppressants, the potassium-competitive acid blockers or acid pump antagonists.1 PF-3716556 inhibited H+/K+-ATPase activity in porcine membrane vesicles, as well as canine and human recombinant cells under ion-leaky conditions (pIC50s = 6.026, 6.038, and 6.009, respectively). PF-3716556 showed 3-fold greater inhibition than revaprazan in ion-tight (neutral pH) conditions. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mori, H.,Tonai-Kachi, H.,Ochi, Y., et al. N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J. Pharmacol. Exp. Ther. 328(2), 671-679 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 394.5 |
| 分子式 | C22H26N4O3 |
| CAS号 | 928774-43-0 |
| 稳定性 | ≥ 2 years |
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