PFK15
货号：
17689-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 17689-5mg |
| 描述 | 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a bifunctional enzyme that contains distinct domains for the phosphorylation of fructose 6-phosphate and the dephosphorylation of fructose 2,6-bisphosphate. PFKFB3 protein expression is elevated in most tumor types.1,2 PFK15 is a selective inhibitor of PFKFB3 (IC50 = 207 nM).3 It has no significant inhibitory effect on any member of a panel of 96 other kinases, and does not inhibit purified 6-phosphofructo-1-kinase, hexokinase, phosphoglucose isomerase, or PFKFB4. PFK15 rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Atsumi, T.,Chesney, J.,Metz, C., et al. High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Research 62(20), 5881-5887 (2002).
2.Seo, M.,Kim, J.D.,Neau, D., et al. Structure-based development of small molecule PFKFB3 inhibitors: A framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6(9), 1-12 (2011).
3.Clem, B.F.,ONeal, J.,Tapolsky, G., et al. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Molecular Cancer Therapeutics 12(8), 1461-1470 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 260.3 |
| 分子式 | C17H12N2O |
| CAS号 | 4382-63-2 |
| 稳定性 | ≥ 2 years |
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