(E)-2-Hexadecenal
货号：
17566-500ug 基本售价：
686.0 元 规格：
500 ug
产品信息
概述| 货号 | 17566-500ug |
| 描述 | Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal is a sphingolipid degradation product resulting from the action of S1P lyase. It can be further oxidized to (2E)-hexadecenoic acid by long-chain fatty aldehyde dehydrogenase prior to activation via coupling to coenzyme A. (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.1 It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.2 |
| 别名 | trans-2-Hexadecenal; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kumar, A.,Byun, H.S.,Bittman, R., et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cellular Signalling 23(7), 1144-1152 (2011).
2.Upadhyaya, P.,Kumar, A.,Byun, H.S., et al. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochemical and Biophysical Research Communications 424(1), 18-21 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 238.4 |
| 分子式 | C16H30O |
| CAS号 | 22644-96-8 |
| 稳定性 | ≥ 2 years |
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