STF-083010
货号：
17370-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 17370-5mg |
| 描述 | STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitroandin vivo.1 STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Item No. 10522), an ER stress inducer.1 This has cytotoxic effects against multiple myeloma cells and drives apoptosis in pancreatic cancer cells.1,2 |
| 别名 | IRE1 Inhibitor I; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Papandreou, I.,Denko, N.C.,Olson, M., et al. Identification of an Ire1 alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117(4), 1311-1314 (2011).
2.Chien, W.,Ding, L.W.,Sun, Q.Y., et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget 5(13), 4881-4894 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 317.4 |
| 分子式 | C15H11NO3S2 |
| CAS号 | 307543-71-1 |
| 稳定性 | ≥ 2 years |
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