SB-705498
货号：
17313-1mg 基本售价：
686.0 元 规格：
1 mg
产品信息
概述| 货号 | 17313-1mg |
| 描述 | The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin (Item No. 92350). SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pKis = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively).1 It has been shown to induce rapid, reversible inhibition of capsaicin (IC50 = 3 nM)-, acid (pH 5.3)-, or heat (50°C; IC50 = 6 nM)-mediated activation of human TRPV1 (at -70 mV).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gunthorpe, M.J.,Hannan, S.L.,Smart, D., et al. Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. Journal of Pharmacology and Experimental Therapeutics 321(3), 1183-1192 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429.2 |
| 分子式 | C17H16BrF3N4O |
| CAS号 | 501951-42-4 |
| 稳定性 | ≥ 2 years |
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