SAR405
货号：
16979-500ug 基本售价：
686.0 元 规格：
500 ug
产品信息
概述| 货号 | 16979-500ug |
| 描述 | SAR405 is an inhibitor of the phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM).1 It is without effect (IC50 > 10,000 nM) on other PI3K isoforms and mTOR. SAR405 alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation.1 SAR405 also synergizes with the mTOR inhibitor everolimus (Item No. 11597) in preventing the proliferation of renal tumor cell lines.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ronan, B.,Flamand, O.,Vescovi, L., et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nature Chemical Biology (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 443.9 |
| 分子式 | C19H21ClF3N5O2 |
| CAS号 | 1523406-39-4 |
| 稳定性 | ≥ 2 years |
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