| 货号 | 16928-5mg |
| 描述 | CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml.1 It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme.1 CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, J.M.,Nelson, F.C.,Levin, J.I., et al. Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. Journal of the American Chemical Society 122, 9648-9654 (2000). 2.Rath, T.,Stöckle, J.,Roderfeld, M., et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol.Lett. 2(3), 483-488 (2011). 3.Wohlauer, M.,Moore, E.E.,Silliman, C.C., et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Critical Care 40(9), 2647-2653 (2012). 4.Wang, M.,Sampson, E.R.,Jin, H., et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Research & Therapy 15(1), 1-11 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 302.4 |
| 分子式 | C17H22N2O3 |
| CAS号 | 307002-71-7 |
| 稳定性 | ≥ 2 years |
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