| 货号 | 16922-5mg |
| 描述 | Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Item No. 13874).1,2 Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.3,4 Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.2 |
| 别名 | Bis(POC)-PMPA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.De Clercq, E. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clin.Microbiol.Rev. 16(4), 569-596 (2003). 2.Robbins, B.L.,Srinivas, R.V.,Kim, C., et al. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPA. Antimicrobial Agents and Chemotherapy 42(3), 612-617 (1998). 3.Balzarini, J.,Vahlenkamp, T.,Egberink, H., et al. Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice. Antimicrobial Agents and Chemotherapy 41(3), 611-616 (1997). 4.Balzarini, J.,Holy, A.,Jindrich, J., et al. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrobial Agents and Chemotherapy 37(2), 332-338 (1993). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 635.5 |
| 分子式 | C19H30N5O10P • C4H4O4 |
| CAS号 | 202138-50-9 |
| 稳定性 | ≥ 2 years |
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