| 货号 | 16890-1mg |
| 描述 | A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3 Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.4 |
| 别名 | 17-trifluoromethylphenyl trinor PGF2α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Woodward, D.F.,Krauss, A.H.P.,Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Survey of Ophthalmology 45, S337-S345 (2001). 2.Stjernschantz, J.W. From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture. Investigative Ophthalmology & Visual Science 42(6), 1134-1145 (2001). 3.Sorbera, L.A., and Castañer, J. Travoprost. Drugs of the Future 25, 41-45 (2000). 4.deLong, M.A.,Amburgey, J.,Taylor, C., et al. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorganic & Medicinal Chemistry Letters 10, 1519-1522 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 456.5 |
| 分子式 | C24H31O5F3 |
| CAS号 | 221246-34-0 |
| 稳定性 | ≥ 1 year |
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