Monocrotaline
货号：
16666-50mg 基本售价：
686.0 元 规格：
50 mg
产品信息
概述| 货号 | 16666-50mg |
| 描述 | Monocrotaline is a natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension.1,2 It is metabolized by cytochrome P450 3A4 in the liver to monocrotaline pyrrole. Administration of monocrotaline or its metabolite monocrotaline pyrrole to rats causes progressive lung injury featuring pulmonary vascular remodeling, pulmonary hypertension, and compensatory right heart hypertrophy.1,2 |
| 别名 | Crotaline;MCT;NSC 28693; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gomez-Arroyo, J.G.,Farkas, L.,Alhussaini, A.A., et al. The monocrotaline model of pulmonary hypertension in perspective. American Journal of Physiology.Lung Cellular and Molecular Physiology 302(4), L363-L369 (2012).
2.Maarman, G.,Lecour, S.,Butrous, G., et al. A comprehensive review: The evolution of animal models in pulmonary hypertension research; are we there yet? Pulm.Circ. 3(4), 739-756 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 325.4 |
| 分子式 | C16H23NO6 |
| CAS号 | 315-22-0 |
| 稳定性 | ≥ 2 years |
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