| 货号 | 16494-500mg |
| 描述 | n-Dodecyl-β-D-maltoside (DDM) is a non-ionic detergent commonly used to solubilize membrane-associated proteins.1,2 In particular, it helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation.3,4,5 The critical micelle concentration of DDM is approximately 0.18 mM in water, decreases in the presence of sodium chloride or sucrose, and increases in urea.6 |
| 别名 | DDM;Dodecyl Maltoside; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ellinger, P.,Kluth, M.,Stindt, J., et al. Detergent screening and purification of the human liver ABC transporters BSEP (ABCB11) and MDR3 (ABCB4) expressed in the yeast Pichia pastoris. PLoS One 8(4), 1-12 (2013). 2.Rouse, S.L.,Marcoux, J.,Robinson, C.V., et al. Dodecyl maltoside protects membrane proteins in vacuo. Biophysical Journal 105(3), 648-656 (2013). 3.Koch, K.W. Purification and identification of photoreceptor guanylate cyclase. The Journal of Biological Chemisty 266(13), 8634-8637 (1991). 4.De Foresta, B.,Henao, F. and Chameil, P. Cancellation of the cooperativity of Ca2+ binding to sarcoplasmic reticulum Ca2+-ATPase by the non-ionic detergent dodecylmaltoside. European Journal of Biochemistry 223(2), 359-369 (1994). 5.Zardeneta, G. and Horowitz, P.M. Micelle-assisted protein folding. Denatured rhodanese binding to cardiolipin-containing lauryl maltoside micelles results in slower refolding kinetics but greater enzyme reactivation. The Journal of Biological Chemisty 267(9), 5811-5816 (1992). 6.Walter, A.,Kuehl, G.,Barnes, K., et al. The vesicle-to-micelle transition of phosphatidylcholine vesicles induced by nonionic detergents: Effects of sodium chloride, sucrose and urea. Biochimica et Biophysica Acta 1508(1-2), 20-33 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 510.6 |
| 分子式 | C24H46O11 |
| CAS号 | 69227-93-6 |
| 稳定性 | ≥ 2 years |
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