JW 55
货号：
16260-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 16260-5mg |
| 描述 | JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 µM, respectively).1 By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM).1 It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.1 |
| 别名 | Tankyrase 1/2 Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Waaler, J.,Machon, O.,Tumova, L., et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 72(11), 2822-2832 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 434.5 |
| 分子式 | C25H26N2O5 |
| CAS号 | 664993-53-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
