CK-636
货号：
16243-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 16243-5mg |
| 描述 | Actin-related protein 3 (Arp3) heterodimerizes with Arp2 to form the Arp2/3 complex, which is involved in actin polymerization in a range of cell types. CK-636 is an inhibitor of Arp2/3 complex action that binds the complex and inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC50s = 4, 32, and 24 µM, respectively).1 It is cell permeable, as it prevents actin polymerization and the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50 = 22 µM).1 CK-636 is used to explore the role of Arp2/3 complex in cellular functions, including epidermal barrier formation and T cell migration.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nolen, B.J.,Tomasevic, N.,Russell, A., et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460(7258), 1031-1034 (2009).
2.Zhou, K.,Muroyama, A.,Underwood, J., et al. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proceedings of the National Academy of Sciences of the United States of America 110(40), E3820-E3829 (2013).
3.Kwon, K.W.,Park, H. and Doh, J. Migration of T cells on surfaces containing complex nanotopography. PLoS One 8(9), 1-6 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 284.4 |
| 分子式 | C16H16N2OS |
| CAS号 | 442632-72-6 |
| 稳定性 | ≥ 2 years |
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