BMS 833923
货号：
16240-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 16240-5mg |
| 描述 | Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors.1 BMS 833923 is an orally bioavailable inhibitor of Smo.2,3 It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models. |
| 别名 | XL 139; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ruiz-Gómez, A.,Molnar, C.,Holguín, H., et al. The cell biology of Smo signalling and its relationships with GPCRs. Biochimica et Biophysica Acta 1768(4), 901-912 (2007).
2.Sandhiya, S.,Melvin, G.,Kumar, S.S., et al. The dawn of hedgehog inhibitors: Vismodegib. J.Pharmacol.Pharmacother. 4(1), 4-7 (2013).
3.Lin, T.L. and Matsui, W. Hedgehog pathway as a drug target: Smoothened inhibitors in development. OncoTargets and Therapy 5, 47-58 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 473.6 |
| 分子式 | C30H27N5O |
| CAS号 | 1059734-66-5 |
| 稳定性 | ≥ 2 years |
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