PluriSln 1
货号：
16161-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 16161-5mg |
| 描述 | PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs).1 PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing progenitor and differentiated cells.1 Because PluriSln 1 can selectively eliminate undifferentiated hPSCs, it was developed as a strategy to prevent tumorigenic risk from residual undifferentiated cells used during stem cell therapy. In immunocompromised mice, PluriSln 1 has been shown to effectively prevent teratoma formation from undifferentiated hPSCs.1 |
| 别名 | NSC 14613;N’-phenyl-hydrazine-Isonicotinic acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ben-David, U.,Gan, Q.F.,Golan-Lev, T., et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12(2), 167-179 (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 213.2 |
| 分子式 | C12H11N3O |
| CAS号 | 91396-88-2 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
