SMAD3 Inhibitor, SIS3
货号：
15945-500ug 基本售价：
686.0 元 规格：
500 ug
产品信息
概述| 货号 | 15945-500ug |
| 描述 | SMAD3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation (IC50 = 3 µM) without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.1 It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jinnin, M.,Ihn, H. and Tamaki, K. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-induced extracellular matrix expression. Molecular Pharmacology 69(2), 597-607 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 453.5 |
| 分子式 | C28H27N3O3 |
| CAS号 | 1009104-85-1 |
| 稳定性 | ≥ 2 years |
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