JNK Inhibitor IX
货号：
15624-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 15624-5mg |
| 描述 | c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens.1 They have been implicated in neurodegeneration, rheumatoid arthritis, inflammation, cancer, and diabetes. JNK1 and JNK2 are widely expressed throughout the body whereas JNK3 is predominantly distributed in the brain. JNK Inhibitor IX is a thienylnaphthamide compound that targets the ATP binding site of JNK2 and JNK3, disrupting activity with pIC50 values of 6.5 and 6.7, respectively.2 It demonstrates little activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50< 5.0).2 |
| 别名 | c-Jun N-terminal Kinase Inhibitor IX;TCS JNK 5a; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cowan, K.J. and Storey, K.B. Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stress. Journal of Experimental Biology 206, 1107-1115 (2003).
2.Angell, R.M.,Atkinson, F.L.,Brown, M.J., et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorganic & Medicinal Chemistry Letters 17(5), 1296-1301 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 332.4 |
| 分子式 | C20H16N2OS |
| CAS号 | 312917-14-9 |
| 稳定性 | ≥ 2 years |
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