Eplerenone
货号：
15616-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 15616-5mg |
| 描述 | Eplerenone is a potassium-sparing diuretic that selectively blocks aldosterone activation of the mineralcorticoid receptor (IC50 = 122 nM), demonstrating little activity towards other steroid receptors (IC50 > 9 µM for glucocorticoid, androgen, progesterone, and estrogen receptors).1 Aldosterone antagonists such as this compound have been indicated for the treatment of hypertension and heart failure.2 |
| 别名 | Epoxymexrenone;Inspra; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Meyers, M.J.,Arhancet, G.B.,Hockerman, S.L., et al. Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. Journal of Medicinal Chemistry 53, 5979-6002 (2010).
2.Craft, J. Eplerenone (Inspra), a new aldosterone antagonist for the treatment of systemic hypertension and heart failure. Proc.(Bayl.Univ.Med.Cent.) 17(2), 217-220 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 414.5 |
| 分子式 | C24H30O6 |
| CAS号 | 107724-20-9 |
| 稳定性 | ≥ 2 years |
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