| 货号 | 15606-1mg |
| 描述 | Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties.1 Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells.1,2,3 The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells.1 Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.3,4,5 |
| 别名 | NSC 261037;Ro 7-0582;SR 1354; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brown, J.M. The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles. Int.J.Radiat.Oncol.Biol.Phys. 8(3-4), 675-682 (1982). 2.Josephy, P.D.,Palcic, B. and Skarsgard, L.D. In vitro metabolism of misonidazole. British Journal of Cancer 43(4), 443-450 (1981). 3.Handley, M.G.,Medina, R.A.,Nagel, E., et al. PET imaging of cardiac hypoxia: Opportunities and challenges. Journal of Molecular and Cellular Cardiology 51(5), 640-650 (2011). 4.Bache, M.,Kappler, M.,Said, H.M., et al. Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies. Current Medicinal Chemistry 15(4), 322-338 (2008). 5.Mendichovszky, I. and Jackson, A. Imaging hypoxia in gliomas. Br.J.Radiol. 84(Spec No 2), S145-S158 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 201.2 |
| 分子式 | C7H11N3O4 |
| CAS号 | 13551-87-6 |
| 稳定性 | ≥ 2 years |
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