| 货号 | 15509-10mg |
| 描述 | Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.1 Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.2 When administered to rats at 0.5-5 μM, PANS affects glomerular epithelial cell adhesion, reducing α3β1 integrin expression.3 PANS also has been shown to decrease nephrin and podocin expression.4 |
| 别名 | NSC 3056;PANS; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Azzam, M.E. and Algranati, I.D. Mechanism of puromycin action: Fate of ribosomes after release of nascent protein chains from polysomes. Proc.Nat.Acad.Sci.USA 70(12), 3866-3869 (1973). 2.Furness, P.N. and Harris, K. An evaluation of experimental models of glomerulonephritis. International Journal of Experimental Pathology 75(1), 9-22 (1994). 3.Krishnamurti, U.,Zhou, B.,Fan, W.W., et al. Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells. Journal of the American Society of Nephrology 12(4), 758-766 (2001). 4.Guan, N.,Ding, J.,Deng, J., et al. Key molecular events in puromycin aminonucleoside nephrosis rats. Pathology International 54(9), 703-711 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 294.3 |
| 分子式 | C12H18N6O3 |
| CAS号 | 58-60-6 |
| 稳定性 | ≥ 2 years |
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