| 货号 | 15414-10mg |
| 描述 | The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis.1 Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM).2 It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans.3 Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.3 Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.4,5 |
| 别名 | Itabastatin;Itavastatin;NK 104; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pahan, K. Lipid-lowering drugs. Cell Mol.Life Sci. 63(10), 1165-1178 (2006). 2.Aoki, T.,Nishimura, H.,Nakagawa, S., et al. Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittel-Forschung 47, 904-909 (1997). 3.Mukhtar, R.Y.,Reid, J. and Reckless, J.P. Pitavastatin. International Journal of Clinical Practice 59(2), 239-252 (2005). 4.Ikeda, K.,Takahashi, T.,Yamada, H., et al. Effect of intensive statin therapy on regression of carotid intima-media thickness in patients with subclinical carotid atherosclerosis (a prospective, randomized trial: PEACE (Pitavastatin Evaluation of Atherosclerosis Regression by Intensive Cholesterol-lowering Therapy) study). Eur.J.Prev.Cardiol. 20(6), 1069-1079 (2013). 5.Saka, M.,Obata, K.,Ichihara, S., et al. Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. Journal of Cardiovascular Pharmacology 47(6), 770-779 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 881 |
| 分子式 | [C25H24FNO4]2 • Ca |
| CAS号 | 147526-32-7 |
| 稳定性 | ≥ 2 years |
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