| 货号 | 15393-5mg |
| 描述 | BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M1receptor.1 The effective range for potentiation of M1 in cells by BQCA is 0.1 to 100 μM with an inflection point value of 845 nM when 3 nM acetylcholine is used.1 BQCA displays no potentiation, agonism, or antagonism at other mAChRs at concentrations up to 100 μM.1 It has excellent brain penetration and increases the firing rate of medial prefrontal cortex neurons in vivo in rats.2 BQCA prevents scopolamine-induced memory deficits in both contextual fear conditioning and a spontaneous alternation task in mice.1,3 It also restores impairment in reversal learning in a mouse model of Alzheimer’s disease and improves memory performance in rats.2,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ma, L.,Seager, M.A.,Wittman, M., et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proceedings of the National Academy of Sciences of the United States of America 106(37), 15950-15955 (2009). 2.Shirey, J.K.,Brady, A.E.,Jones, P.J., et al. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. Journal of Neuroscience 29(45), 14271-14286 (2009). 3.Chambon, C.,Jatzke, C.,Wegener, N., et al. Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication. European Journal of Pharmacology 697(1-3), 73-80 (2012). 4.Galloway, C.R.,Lebois, E.P.,Shagarabi, S., et al. Effects of selective activation of M1 and M4 muscarinic receptors on object recognition memory performance in rats. Pharmacology 93(1-2), 57-64 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 309.3 |
| 分子式 | C18H15NO4 |
| CAS号 | 338747-41-4 |
| 稳定性 | ≥ 2 years |
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