SF1670
货号：
15368-1mg 基本售价：
686.0 元 规格：
1 mg
产品信息
概述| 货号 | 15368-1mg |
| 描述 | Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids including Akt and phosphatidylinositol 3,4,5-trisphosphate (PIP3). SF1670 specifically binds to the active site of PTEN inhibiting its activity with an IC50 value of 2 μM.1,2 At nanomolar concentrations it increases cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes.2,3 Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Garlich, J.R.,Durden, D.L.,Georgiadis, T.M., et al. PTEN inhibitors. PCT/US2005/011626, 1-85 (2005).
2.Rosivatz, E.,Matthews, J.G.,McDonald, N.Q., et al. A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem. Biol. 1(12), 780-790 (2006).
3.Li, Y.,Prasad, A.,Jia, Y., et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117(24), 6702-6713 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 307.4 |
| 分子式 | C19H17NO3 |
| CAS号 | 345630-40-2 |
| 稳定性 | ≥ 2 years |
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