| 货号 | 15359-5mg |
| 描述 | Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.1 Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface.2 RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen.3,4 RGDS interacts with α5β1 and αVβ3 integrins.5 This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).3,4 It also blocks the attachment of certain pathogens to cells.6,7 RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor (IC50 = ~10 μM).3,8,9 The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.10,11 |
| 别名 | Fibronectin Inhibitor;H-Arg-Gly-Asp-Ser-OH; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ruoslahti, E. and Öbrink, B. Common principles in cell adhesion. Experimental Cell Research 227, 1-11 (1996). 2.Stömblad, S. and Cheresh, D.A. Integrins, angiogenesis and vascular cell survival. Chemistry & Biology 3, 881-885 (1996). 3.Haverstick, D.M.,Cowan, J.F.,Yamada, K.M., et al. Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin. Blood 66(4), 946-952 (1985). 4.Pierschbacher, M.D. and Ruoslahti, E. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309(5963), 30-33 (1984). 5.Basani, R.B.,DAndrea, G.,Mitra, N., et al. RGD-containing peptides inhibit fibrinogen binding to platelet αIIbβ3 by inducing an allosteric change in the amino-terminal portion of αIIb. The Journal of Biological Chemisty 276(17), 13975-13981 (2014). 6.Pottratz, S.T. and Martin, W.J., II. Mechanism of Pneumocystis carinii attachment to cultured rat alveolar macrophages. Journal of Clinical Investigation 86(5), 1678-1683 (1990). 7.Thomas, D.D.,Baseman, J.B. and Alderete, J.F. Fibronectin tetrapeptide is target for syphilis spirochete cytadherence. Journal of Experimental Medicine 162(5), 1715-1719 (1985). 8.Gartner, T.K. and Bennett, J.S. The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets. The Journal of Biological Chemisty 260(22), 11891-11894 (1985). 9.Ginsberg, M.,Pierschbacher, M.D.,Ruoslahti, E., et al. Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion. The Journal of Biological Chemisty 260(7), 3931-3936 (1985). 10.Dekkers, B.G.J.,Bos, I.S.T.,Gosens, R., et al. The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. American Journal of Respiration and Critical Care Medicine 181(6), 556-565 (2010). 11.Moon, C.,Han, J.R.,Park, H.J., et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respiratory Research 10, 18 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 433.4 |
| 分子式 | C15H27N7O8 |
| CAS号 | 91037-65-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |