Probucol
货号：
15043-5g 基本售价：
686.0 元 规格：
5 g
产品信息
概述| 货号 | 15043-5g |
| 描述 | Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.1 Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.1 Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.2 In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.3 |
| 别名 | DH 581;Lorelco;NSC 86225;NSC 652160; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yamamoto, A. A uniqe antilipidemic drug--Probucol. Journal of Atherosclerosis and Thrombosis 15(6), 304-305 (2013).
2.Favari, E.,Zanotti, I.,Zimetti, F., et al. Probucol inhibits ABCA1-mediated cellular lipid efflux. Arteriosclerosis, Thrombosis, and Vascular Biology 24(12), 2345-2350 (2004).
3.Colle, D.,Santos, D.B.,Moreira, E.L.G., et al. Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats. PLoS One 8(6), e67658 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 516.8 |
| 分子式 | C31H48O2S2 |
| CAS号 | 23288-49-5 |
| 稳定性 | ≥ 2 years |
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