| 货号 | 14984-25mg |
| 描述 | Zoledronic acid is a third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption.1 It has a high affinity for hydroxyapatite (Ki = 3.47 μM) and binds directly to mineralized bone where it decreases bone resorption by inhibiting osteoclast proliferation and inducing osteoclast apoptosis.2,1 At μM concentrations, zoledronic acid demonstrates antitumor effects in vitro against breast, prostate, and myeloma cancer cells by inducing cytostasis and prevents bone metastases through its inhibitory effects on adhesion molecules, tumor cell invasion, and angiogenesis.1 Zoledronic acid has been used in the treatment of osteoporosis, Paget’s disease, metastatic bone disease, multiple myeloma, hypercalcemia of malignancy, and skeletal-related events associated with metastatic castrate-resistant prostate cancer.1,3,4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, E.C. and David, L.E. Zoledronic acid: A new parenteral bisphosphonate. Clinical Therapeutics 25(11), 2669-2708 (2003). 2.Nancollas, G.H.,Tang, R.,Phipps, R.J., et al. Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite. Bone 38(5), 617-627 (2006). 3.Räkel, A.,Boucher, A. and Ste-Marie, L.G. Role of zoledronic acid in the prevention and treatment of osteoporosis. Clinical Interventions in Aging 6, 89-99 (2011). 4.El-Amm, J.,Freeman, A.,Patel, N., et al. Bone-targeted therapies in metastatic castration-resistant prostate cancer: Evolving paradigms. Prostate Cancer 2013, 1-10 (2013). 5.Major, P. The use of zoledronic acid, a novel, highly potent bisphosphonate, for the treatment of hypercalcemia of malignancy. Oncologist 7(6), 481-491 (2002). 6.Michou, L. and Brown, J.P. Emerging strategies and therapies for treatment of Paget’s disease of bone. Drug Des.Devel.Ther. 5, 225-239 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 290.1 |
| 分子式 | C5H10N2O7P2 • H2O |
| CAS号 | 165800-06-6 |
| 稳定性 | ≥ 2 years |
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