| 货号 | 14905-5mg |
| 描述 | L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine viahercynine.1 Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression.2,3 In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine.2,4,5 Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.6 |
| 别名 | 2-Mercaotohistidine betaine;NSC 7175; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Askari, A. and Melville, D.B. The reaction sequence in ergothioneine biosynthesis: Hercynine as an intermediate. The Journal of Biological Chemisty 237, 1615-1618 (1962). 2.Rahman, I. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochimica et Biophysica Acta 1822(5), 714-728 (2012). 3.Misiti, F.,Castagnola, M.,Zuppi, C., et al. Role of ergothioneine on S-nitrosoglutathione catabolism. Biochemistry Journal 356(3), 799-804 (2001). 4.Cheah, I.K. and Halliwell, B. Ergothioneine; antioxidant potential, physiological function and role in disease. Biochimica et Biophysica Acta 1822, 784-793 (2012). 5.Aruoma, O.I.,Spencer, J.P.E. and Mahmood, N. Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food and Chemical Toxicology 37(11), 1043-1053 (1999). 6.Nakamura, T.,Yoshida, K.,Yabuuchi, H., et al. Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). Biological and Pharmaceutical Bullentin 31(8), 1580-1584 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 229.3 |
| 分子式 | C9H15N3O2S |
| CAS号 | 497-30-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |