| 货号 | 14742-1mg |
| 描述 | Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14.1,2,3,4 It also potently inhibits TNFα-converting enzyme (IC50 = 14.9 nM).2 Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.5 Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).6 |
| 别名 | BB-94; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fray, M.J.,Burslem, M.F. and Dickinson, R.P. Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3 group chirality. Bioorganic & Medicinal Chemistry Letters 11(4), 567-570 (2001). 2.Fray, M.J.,Dickinson, R.P.,Huggins, J.P., et al. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. Journal of Medicinal Chemistry 46(16), 3514-3525 (2003). 3.Sheppard, G.S.,Florjancic, A.S.,Giesler, J.R., et al. Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors. Bioorganic & Medicinal Chemistry Letters 8(22), 3251-3256 (1998). 4.Yamamoto, M.,Tsujishita, H.,Hori, N., et al. Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. Journal of Medicinal Chemistry 41(8), 1209-1217 (1998). 5.Chaudhary, A.K.,Pandya, S.,Ghosh, K., et al. Matrix metalloproteinase and its drug targets therapy in solid and hematological malignancies: An overview. Mutation Research 753(1), 7-23 (2013). 6.Bailey, S.,Bolognese, B.,Buckle, D.R., et al. Selective inhibition of low affinity IgE receptor (CD23) processing. Bioorganic & Medicinal Chemistry Letters 8(1), 29-34 (1998). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.6 |
| 分子式 | C23H31N3O4S2 |
| CAS号 | 130370-60-4 |
| 稳定性 | ≥ 2 years |
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