| 货号 | 14684-1g |
| 描述 | 3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.1,2,3 This compound is a natural toxin of certain plants and fungi. Administration of 3-NP to rats (12 mg/kg per day) produces progressive striatal degeneration, while lower doses (8 mg/kg daily) in nonhuman primates results in neuropathologic and clinical features of Huntington’s disease.1 Conversely, Huntington’s disease results in a loss of Complex II activity.2 3-NP also induces convulsions and is used to examine interventions effective in a mouse model of epilepsy.4 |
| 别名 | β-Nitropropionic Acid;3-NP;NSC 64266; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brouillet, E.,Hantraye, P.,Ferrante, R.J., et al. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proceedings of the National Academy of Sciences of the United States of America 92, 7105-7109 (1995). 2.Huang, L.,Sun, G.,Cobessi, D., et al. 3-Nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. The Journal of Biological Chemisty 281(9), 5965-5972 (2006). 3.Ayala-Peña, S. Role of oxidative DNA damage in mitochondrial dysfunction and Huntington’s disease pathogenesis. Free Radical Biology & Medicine 62, 102-110 (2013). 4.Zuchora, B.,Tursji, W.A.,Wielosz, M., et al. Protective effect of adenosine receptor agonists in a new model of epilepsy--seizures evoked by mitochondrial toxin, 3-nitropropionic acid, in mice. Neuroscience Letters 305(2), 91-94 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 119.1 |
| 分子式 | C3H5NO4 |
| CAS号 | 504-88-1 |
| 稳定性 | ≥ 2 years |
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