| 货号 | 14599-5mg |
| 描述 | WAY-100635 is a potent, silent antagonist of serotonin 5-HT1A receptors with an IC50 value of 2.2 nM (Ki = 0.8 nM) for inhibiting 5-HT1A receptors in rat hippocampal membranes.1,2 Because it displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes, WAY-100635 is classically used to examine the distribution and function of 5-HT1Areceptors.3 However, WAY-100635 has also been shown to exhibit agonist activity at dopamine D4 receptors (Kd = 2.4 nM).4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zhuang, Z.P.,Kung, M.P. and Kung, H.F. Synthesis and evaluation of 4-(2-methoxyphenyl)-1-[2-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): A new iodinated 5-HT1A ligand. Journal of Medicinal Chemistry 37(10), 1406-1407 (1994). 2.Mensonides-Harsema, M.M.,Liao, Y.,Böttcher, H., et al. Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635. Journal of Medicinal Chemistry 43(3), 432-439 (2000). 3.Forster, E.A.,Cliffe, I.A.,Bill, D.J., et al. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. European Journal of Pharmacology 281(1), 81-88 (1995). 4.Chemel, B.R.,Roth, B.L.,Armbruster, B., et al. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl) 188(2), 244-251 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 538.6 |
| 分子式 | C25H34N4O2 • C4H4O4 |
| CAS号 | 1092679-51-0 |
| 稳定性 | ≥ 2 years |
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