| 货号 | 14531-25mg |
| 描述 | N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively).1,2 It is a weak inhibitor of TRPV1.2 ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.3,4 |
| 别名 | ACA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kraft, R.,Grimm, C.,Frenzel, H., et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. British Journal of Pharmacology 148(3), 264-273 (2006). 2.Harteneck, C.,Frenzel, H. and Kraft, R. N-(p-amylcinnamoyl)anthranilic acid (ACA): A phospholipase A2 inhibitor and TRP channel blocker. Cardiovascular Drug Reviews 25(1), 61-75 (2007). 3.Konrad, R.J.,Jolly, Y.C.,Major, C., et al. Inhibition of phospholipase A2 and insulin secretion in pancreatic islets. Biochimica et Biophysica Acta 1135(2), 215-220 (1992). 4.Simonsson, E.,Karlsson, S. and Ahrén, B. Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets. Diabetes 47(9), 1436-1443 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 337.4 |
| 分子式 | C21H23NO3 |
| CAS号 | 110683-10-8 |
| 稳定性 | ≥ 2 years |
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