| 货号 | 14461-5mg |
| 描述 | Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.1 AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM.2,3,4 It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.5 |
| 别名 | N-Ala-Ala-Phe-CMK;Tripeptidyl Peptidase Inhibitor II; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Macpherson, E.,Tomkinson, B.,Bålöw, R.M., et al. Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity. Biochemistry Journal 248(1), 259-263 (1987). 2.Geier, E.,Pfeifer, G.,Wilm, M., et al. A giant protease with potential to substitute for some functions of the proteasome. Science 283(5404), 978-981 (1999). 3.Hilbi, H.,Puro, R.J. and Zychlinsky, A. Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Infection and Immunity 68(10), 5502-5508 (2000). 4.Lévy, F.,Burri, L.,Morel, S., et al. The final n-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases. Journal of Immunopharmacology 169(8), 4161-4167 (2002). 5.Stoltze, L.,Schirle, M.,Schwarz, G., et al. Two new proteases in the MHC class I processing pathway. Nature Immunology 1(5), 413-418 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 453.8 |
| 分子式 | C16H22ClN3O3 • CF3COOH |
| CAS号 | 184901-82-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |