A-771726
货号：
14404-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 14404-5mg |
| 描述 | A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively).1 At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle.1 A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.2 |
| 别名 | Flucyamide;HMR 1726;SU 20;Teriflunomide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Breedveld, F.C. and Dayer, J.M. Leflunomide: Mode of action in the treatment of rheumatoid arthritis. Annals of the Rheumatic Diseases 59, 841-849 (2000).
2.Burger, D.,Begué-Pastor, N.,Benavent, S., et al. The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E2, matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes. Rheumatology 42, 89-96 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 270.2 |
| 分子式 | C12H9F3N2O2 |
| CAS号 | 163451-81-8 |
| 稳定性 | ≥ 2 years |
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