Amifostine (hydrate)
货号：
14398-50mg 基本售价：
686.0 元 规格：
50 mg
产品信息
概述| 货号 | 14398-50mg |
| 描述 | Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities.1 Because of the differential expression of alkaline phosphatase in normal versus neoplastic tissues, the cytoprotection conferred by amifostine is selective, enabling as much as 100-fold greater accumulation of WR 1065 in normal tissues than in tumor cells.1 Amifostine has been used to reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents.1 In mouse fibroblasts and various cancer cells, amifostine (IC50 = 4 mM) has been shown to activate p53 protein, to induce the expression of the cyclin-dependent kinase inhibitor p21, and to arrest cells at the G1/S transition through a p53-dependent mechanism.2 |
| 别名 | Ethyol;WR 2721; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kouvaris, J.R.,Kouloulias, V.E. and Vlahos, L.J. Amifostine: The first selective-target and broad-spectrum radioprotector. Oncologist 12(6), 738-747 (2007).
2.Lee, E.J.,Gerhold, M.,Palmer, M.W., et al. p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. British Journal of Cancer 88(5), 754-759 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 268.3 |
| 分子式 | C5H15N2O3PS • 3H2O |
| CAS号 | 112901-68-5 |
| 稳定性 | ≥ 2 years |
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