Phenamil (methanesulfonate)
货号：
14308-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 14308-5mg |
| 描述 | Transient receptor potential polycystin-L (TRPP3) is a member of the TRP superfamily of cation channels that is localized to a subset of taste receptor cells in the tongue and to neurons surrounding the central canal of the spinal cord. Phenamil is a second generation analog of amiloride (hydrochloride) (Item No. 14409), the prototypical epithelial sodium channel (ENaC) blocker that inhibits TRPP3-mediated Ca2+-activated currents with an IC50 value of 0.14 μM.1 It is also known to inhibit ENaC (IC50 = 10 nM).2 ENaC blockers such as phenamil have been proposed as a therapy to restore mucus clearance in cystic fibrosis airways. Phenamil inhibits active sodium transport of human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dai, X.Q.,Ramji, A.,Liu, Y., et al. Inhibition of TRPP3 channel by amiloride and analogs. Molecular Pharmacology 72(6), 1576-1585 (2007).
2.Lingueglia, E.,Voilley, N.,Lazdunski, M., et al. Physiological society symposium: Ion channels in health and disease. Molecular biology of the amiloride-sensitive epithelial Na+ channel. Experimental Physiology 81, 483-492 (1996).
3.Hirsh, S.J.,Sabater, J.R.,Zamurs, A., et al. Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease. Journal of Pharmacology and Experimental Therapeutics 311(3), 929-938 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 401.8 |
| 分子式 | C12H12ClN7O • CH3SO3H |
| CAS号 | 1161-94-0 |
| 稳定性 | ≥ 2 years |
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