| 货号 | 14181-500mg |
| 描述 | Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste.1,2 By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton.3,4 More recently, amlexanox has been found to inhibit the non-canonical IKK-ε and TANK-binding kinase 1.5 |
| 别名 | AA 673;Aphthasol™;CHX 3673;Elics;Solfa™; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bell, J. Amlexanox for the treatment of recurrent aphthous ulcers. Clinical Drug Investigation 25(9), 555-566 (2005). 2.Iwama, T.,Komatsu, N.,Shikada, K.i., et al. Reversing effect of anti-asthmatic drugs on bronchoconstriction induced by antigen challenge and histamine in anesthetized guinea pigs. Japan.J.Pharmacol. 58, 19-25 (1992). 3.Shishibori, T.,Oyama, Y.,Matsushita, O., et al. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Biochemistry Journal 338, 583-589 (1999). 4.Landriscina, M.,Prudovsky, I.,Carreira, C.M., et al. Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro. The Journal of Biological Chemisty 275(42), 32753-32762 (2000). 5.Reilly, S.M.,Chiang, S.H.,Decker, S.J., et al. An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nature Medicine (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 298.3 |
| 分子式 | C16H14N2O4 |
| CAS号 | 68302-57-8 |
| 稳定性 | ≥ 2 years |
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