WIN 18,446
货号：
14018-50mg 基本售价：
686.0 元 规格：
50 mg
产品信息
概述| 货号 | 14018-50mg |
| 描述 | WIN 18,446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism.1 In this way, WIN 18,446 suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis.2,1 As a result, WIN 18,446 may cause infertility in males.2,1 |
| 别名 | NSC 59354; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Amory, J.K.,Muller, C.H.,Shimshoni, J.A., et al. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. Journal of Andrology 32(1), 111-119 (2011).
2.Hogarth, C.A.,Evanoff, R.,Snyder, E., et al. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biology of Reproduction 84(5), 957-965 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 366.1 |
| 分子式 | C12H20Cl4N2O2 |
| CAS号 | 1477-57-2 |
| 稳定性 | ≥ 2 years |
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