| 货号 | 13995-1g |
| 描述 | Rotenone is a classical inhibitor of complex I of the mitochondrial electron transport chain, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC50 values of 28.8 and 5.1 nM, respectively.1 In animals, it drives neurodegeneration, resulting in features similar to some behavioral and neuropathological aspects of Parkinson’s disease.2,3,4 This naturally-occurring isoflavonoid is commonly used as an insecticide, piscicide, and pesticide.5 |
| 别名 | Nicouline;NSC 8505;NSC 26258;Tubatoxin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tormo, J.R.,Gallardo, T.,Peris, E., et al. Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives. Bioorganic & Medicinal Chemistry Letters 13(22), 4101-4105 (2003). 2.Uversky, V.N. Neurotoxicant-induced animal models of Parkinson’s disease: Understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell and Tissue Research 318(1), 225-241 (2004). 3.Freestone, P.S.,Chung, K.K.,Guatteo, E., et al. Acute action of rotenone on nigral dopaminergic neurons--involvement of reactive oxygen species and disruption of Ca2+ homeostasis. European Journal of Neuroscience 30(10), 1849-1859 (2009). 4.Xiong, N.,Long, X.,Xiong, J., et al. Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models. Crit.Rev.Toxicol. 42(7), 613-632 (2012). 5.Soloway, S.B. Naturally occurring insecticides. Environmental Health Perspectives 14, 109-117 (1976). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 394.4 |
| 分子式 | C23H22O6 |
| CAS号 | 83-79-4 |
| 稳定性 | ≥ 2 years |
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