| 货号 | 13687-1mg |
| 描述 | Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.1,2,3 CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively.4 It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Olson, M.F. Applications for ROCK kinase inhibition. Current Opinion in Cell Biology 20, 242-248 (2008). 2.Narumiya, S.,Tanji, M. and Ishizaki, T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Reviews 28, 65-76 (2009). 3.Watanabe, K.,Ueno, M.,Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology 25(6), 681-686 (2007). 4.Morwick, T.,Büttner, F.H.,Cywin, C.L., et al. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. Journal of Medicinal Chemistry 53, 759-777 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 443.5 |
| 分子式 | C25H25N5O3 |
| CAS号 | 1038549-25-5 |
| 稳定性 | ≥ 2 years |
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