| 货号 | 13280-5mg |
| 描述 | Panobinostat is a potent inhibitor of all histone deacetylases (HDACs), with Ki values ranging from 0.6 to 31 nM for HDAC1-11.1,2 Through this action, it leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells.2 It has potential applications in several different forms of cancer as well as in spinal muscular atrophy and HIV therapy.2,3,4,5 |
| 别名 | LBH-589; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wang, H.,Yu, N.,Chen, D., et al. Discovery of (2E)-3-{2-Butyl-1-[2-diethylamino)ethyl]-1H-benzamidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. Journal of Medicinal Chemistry 54(13), 4694-4720 (2011). 2.George, P.,Bali, P.,Annavarapu, S., et al. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood 105(4), 1768-1776 (2005). 3.Song, X.,Wang, J.,Zheng, T., et al. LBH589 inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway. Molecular Cancer 12(1), 114 (2013). 4.Garbes, L.,Riessland, M.,Hölker, I., et al. LBH589 induces up to 10-fold SMN protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate. Human Molecular Genetics 18(19), 3645-3658 (2009). 5.Rasmussen, T.A.,Schmeltz Sogaard, O.,Brinkmann, C., et al. Comparison of HDAC inhibitors in clinical development: Effect on HIV production in latently infected cells and T-cell activation. Hum.Vaccin.Immunother. 9(5), 993-1001 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 349.4 |
| 分子式 | C21H23N3O2 |
| CAS号 | 404950-80-7 |
| 稳定性 | ≥ 2 years |
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