| 货号 | 12006-10mg |
| 描述 | Rottlerin was originally identified as an inhibitor of PKCδ (IC50 = 3 μM), but can also inhibit CAM kinase III and a wide range of protein kinases, including PRAK and MAPKAP-K2(IC50s = 1.9 and 5 μM, respectively).1,2 It can act as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1.3 Rottlerin has also been shown to have neuroprotective effects in an MPTP animal model of Parkinson’s disease.4 |
| 别名 | Mallotoxin;NSC 94525;NSC 56346; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.McGovern, S.L., and Shoichet, B.K. Kinase inhibitors: Not just for kinases anymore. Journal of Medicinal Chemistry 46, 1478-1483 (2003). 2.Davies, S.P.,Reddy, H.,Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemistry Journal 351, 95-105 (2000). 3.Balgi, A.D.,Fonseca, B.D.,Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4(9), 1-15 (2009). 4.Zhang, D.,Anantharam, V.,Kanthasamy, A., et al. Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson’s disease. Journal of Pharmacology and Experimental Therapeutics 322(3), 913-922 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥90% |
| 计算分子量 | 516.5 |
| 分子式 | C30H28O8 |
| CAS号 | 82-08-6 |
| 稳定性 | ≥ 6 months |
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