| 货号 | 11880-1g |
| 描述 | Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer.1,2,3,4 Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.5 Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging).6 However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide.7,8 Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.9 |
| 别名 | BBR 3222;NSC 14879; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Huang, M.T.,Smart, R.C.,Wong, C., et al. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Research 48, 5941-5946 (1988). 2.Conney, A.H.,Lysz, T.,Ferraro, T., et al. Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin. Advances in Enzyme Regulation 31, 385-396 (1991). 3.Iwahashi, H.,Nishizaki, K., and Takagi, I. Cytochrome c catalyzes the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. Biochemistry Journal 361, 57-66 (2002). 4.Sudheer, A.R.,Muthukumaran, S.,Devipriya, N.A., et al. Influence of ferulic acid on nicotine-induced lipid peroxidation, DNA damage and inflammation in experimental rats as compared to N-acetylcysteine. Toxicology 243, 317-329 (2008). 5.Sultana, R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochimica et Biophysica Acta 1822(5), 748-752 (2012). 6.Garrido, J.,Gaspar, A.,Garrido, E.M., et al. Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress. Biochimie 94(4), 961-967 (2012). 7.Sultana, R.,Ravagna, A.,Mohmmad-Abdul, H., et al. Ferulic acid ethyl ester protects neurons against amyloid β-peptide(1-42)-induced oxidative stress and neurotoxicity: Relationship to antioxidant activity. Journal of Neurochemistry 92(4), 749-758 (2005). 8.Joshi, G.,Perluigi, M.,Sultana, R., et al. In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane) dihydrochloride (AAPH) or Fe2+/H2O2: Insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders. Neurochemistry International 48(4), 318-327 (2006). 9.Di Domenico, F.,Perluigi, M.,Foppoli, C., et al. Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes. Free Radical Research 43(4), 365-375 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 222.2 |
| 分子式 | C12H14O4 |
| CAS号 | 4046-02-0 |
| 稳定性 | ≥ 2 years |
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